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METAOD003: A Phase IIa (double-blind, placebo-controlled 4 × 4 Latin Square design) safety study with single doses (9, 27 and 54 mg AOD9604) administered orally (capsules) to 17 healthy, clinically obese males presenting with a BMI ≥ 35 kg/m 2

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A shared major “occlusion-like” syndrome, which was also antagonized by BPC 157 therapy, occurred after intragastric application of absolute alcohol, intraperitoneal application of lithium overdose, or with maintained severe intra-abdominal hypertension, grade III and grade IV [21,22,23]